The main difference between a cross sectional study and a longitudinal study is whether the study examines looks at one point in time (cross sectional) or over a period of time (longitudinal).
Cross sectional studies look at the sample at one point in time. It makes this kind of study good for capturing prevalence (of a condition, of an intervention, or of a belief or perception). However, capturing only one point in time limits the generalizability of the results.
Researchers conduct a survey to measure nurses' understanding of current CAUTI prevention guidelines. The results reflect that cohort of nurses' understanding of CAUTI guidelines at that specific moment in time.
Longitudinal studies look at a sample over multiple points in time. This kind of study is good at measuring changes or shifts.
Researchers conducted 4 surveys over a period of 5 years to measure a cohort of new RNs understanding of current CAUTI prevention guidelines. The results reflect how/if these nurses' understanding of the guidelines has shifted over the period of time the study looks at.